Neural Control of Human Defensive Reactions to Social Threat

Karin Roelofs

(Radboud University)

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Date: May 15, 2019


The ability to control automatic emotional actions constitutes a critical component of emotion regulation during socially threatening situations. For instance, under acute threat, goal directed decision-making depends largely on the capacity to override automatic defensive actions such as freezing reactions or fight-or-flight actions. Distinct parts of the frontal cortex are implicated in regulating these defensive reactions. I will present a number of experimental paradigms by which we assessed neural control over these defensive reactions in humans by combining decision tasks with neural and autonomic measures. The first series of studies indicates that down-regulation of amygdala activity by the anterior prefrontal cortex (aPFC) is involved when people need to override their automatic social approach-avoidance action tendencies. I will show that the functioning of this neural circuitry is sensitive to individual differences in social anxiety and aggression, and I will discuss manipulations of this neural circuitry by steroid hormone administration (i.e. testosterone) and brain stimulation (TMS). […] Together, these series of studies show that distinct frontal regions are implicated in controlling distinct defensive reactions, and that the ability to flexibly shift between different defensive response modes is essential for adequate threat coping. It is this ability that may fail in social emotional disorders such as social anxiety and aggression-related disorders. See

Created: Wednesday, May 15th, 2019